He aha ka PROCYANIDIN B-2 (i unuhi ʻia mai nā ʻāpala)?

He aha ia?

ʻO Procyanidin B-2, he subclass o nā flavonoids i ʻike ʻia e hoʻohana i nā hopena antioxidant ikaika, therapeutic, a me nā hopena anti-inflammatory.

ʻO kēia mau pūhui polyphenol, i loaʻa maʻamau i loko o nā ʻāpala, bale, a me nā hua waina, ua manaʻo ʻia e hana i ka ulu ʻana o ka lauoho i nā hopena hoʻoulu ʻia ma o ka hoʻoulu ʻana i ka ulu ʻana o ka lauoho epithelial cell a me ka hoʻoulu ʻana i ka ulu anagen ikaika i loko o nā hiʻohiʻona vivo murine a ma 6 mahina & 12 mahina. na hoao ana.

Pono oPROCYANIDIN B-2

Nā hana pale e kūʻē i ka hoʻomohala ʻana i ka catagen, ka luku ʻana i ka DNA cellular (apoptosis), a me ka poho lauoho:

Ua nānā kēia haʻawina i ka pilina o Procyanidin b-2 i nā ala hōʻailona TGF-beta, i ʻike ʻia e hoʻoulu i ka pae catagen (ʻo ia ka degenerative hair stage), a me ka mitogen-activated protein kinase cascade (PKC), i hoʻopili ʻia me ka cell. hoonui. Ua hoʻohui kēia haʻawina i ka TGF-beta (1) a me (2) i nā moʻomeheu cell epithelial lauoho a ʻike ʻia ʻo kēia mau ala i hoʻemi ʻia i ka ulu ʻana o ka cell a hoʻoulu i ka apoptosis (ʻo ka apoptosis ka make ʻana o nā cell e hana ʻia ma ke ʻano he ʻāpana maʻamau a mālama ʻia o kahi. ka ulu ʻana a i ʻole ka ulu ʻana o ke kino). Eia naʻe, ʻo ka hoʻohui ʻana o ka procyanidin B-2 i ka moʻomeheu cell hair i hoʻokaʻawale i kēia mau hopena ulu-inhibiting a pale i nā ʻili lauoho mai ka apoptosis.

Ua nānā ʻia ma mua o 1,000 mau mea ʻili kūlohelohe ...

Ua manaʻo ʻia nā proanthocyanidins (me ka procyanidin b-2) mai ka hua waina ma ke ʻano he ʻano kumu maoli no ka ulu ʻana o ka lauoho, ma hope o ka nānā ʻana o nā ʻepekema ma luna o 1,000 mau ʻano mea kanu like ʻole. Ua ʻike lākou ua hoʻonui kēia mau proanthocyanidins i nā cell follicle lauoho i nā ʻiole ma kahi o 230% e pili ana i nā mana (100%) a loaʻa iā ia kahi "hoʻololi lauoho-hoihoi-hoʻololi ʻana mai ka pae telogen a i ka manawa anagen...". No laila, mai loko mai o 1,000 ka nānā ʻana i nā mea kanu, ʻoi aku ka hua waina ma luna o lākou āpau. Hoʻopili ʻia nā mea i loko o nā hua waina a me ko lākou kumu no ka kūleʻa i ka ulu ʻana o ka lauoho ma o kāna mau pūhui phenolic like ʻole, ka mana antioxidant, hoʻomaikaʻi i ke kahe koko, hoʻolaha ʻana i ka collagen a me nā pono ʻē aʻe. (aʻo). ʻO nā ʻano hua waina he ʻano oligomeric proanthocyanidins me ka 3.1% PB-2 wale nō. Makemake mākou i ʻoi aku ka PB-2 maʻiʻo, no laila ʻaʻole hoihoi nā ʻano hua waina no ka ulu ʻana o ka ʻumiʻumi (eia naʻe no ka ulu lauoho).

Nā hopena o ka ulu ʻana o ka lauoho epithelial cell

No ka hoʻopau ʻana i ke ʻano o ka hoʻoulu ʻana i nā hana o kēia mau procyanidins, ua hōʻike kēia haʻawina e hōʻike ana ka procyanidin b-2 i nā hopena hoʻoulu ulu nui no ka ulu ʻana o ka cell epithelial cell. Hōʻike kēia ʻike e loaʻa ana i ka procyanidin b-2 ka hana hoʻoikaika i ka ulu ʻana i nā cell epithelial hair murine ma ka kiʻekiʻe kiʻekiʻe loa o 300% e pili ana i nā mana i loko o kahi moʻomeheu 5 lā, a ua hōʻike pū ʻia hoʻi nā procyanidin oligomers e hoʻoulu i ka induction anagen i loko o ka vivo murine. hoʻohālike ma kahi kokoke i ka ikaika like me ka minoxidil 2%. Ua kū ʻo Procyanidin b-2 ma ke ʻano he polyphenol hoʻonui i ka ulu ʻana, i ka hoʻohālikelike ʻia me PB-3 a me PC-1 (ʻo ia ke kumu ʻaʻole lilo ka hua waina i kumu maikaʻi loa no ka ulu ʻana o ka ʻumiʻumi).

He mea hoihoi e hoʻomaopopo i ka nānā ʻana o kēia haʻawina i ka noi kumuhana o kēia mau oligomers procyanidin me ka 1% wale nō. Hoʻohālikelike kēia haʻawina i kāna 1% kaʻina me ka minoxidil 2%. Hiki ke hoʻohālikelike ʻia kahi kiʻekiʻe kiʻekiʻe (e like me 5%) o ka procyanidin b-2 e hoʻohālikelike maikaʻi me ka Minoxidil 5%.

Hōʻike kēia haʻawina i ka hiki ke hoʻohiki ʻia no ka procyanidin b2 e hoʻohana ʻia ma ke ʻano he mea hoʻoulu ulu lauoho maoli.

Nā hoʻāʻo hoʻāʻo kanaka

Ua noiʻi kēia hoʻokolohua lapaʻau i nā hopena o 1% procyanidin b2 wale nō i ka ulu ʻana o ka lauoho kanaka ma hope o ka hoʻohana ʻana no 6 mau mahina. Ua hana ʻia kahi hoʻokolohua lapaʻau pālua-makapō e pili ana i ka huina o 29 mau kumuhana. ʻO 19 mau kāne ma ka hui procyanidin B-2 a me 10 mau kāne ma ka hui hoʻomalu placebo i hoʻopaʻa ʻia i nā loiloi. ʻAʻole i ʻike ʻia nā hopena ʻino i kēlā me kēia hui.

Nā hualoaʻa:

ʻO ka hoʻonui ʻana i ka nui o nā lauoho a pau ma ka ʻāpana poʻo i koho ʻia (0.5 cm square = 0.25 cm2 area) o nā kumuhana procyanidin B-2 ma hope o ka hoʻāʻo ʻana o 6 mau mahina i ʻoi aku ka nui ma mua o nā kumuhana placebo control group (procyanidin B-2). , 6.68 +/- 5.53 (mean +/- SD)/0.25 cm2, 0.08 +/-; 4,56 (mean +/- SD)/0,25 cm2; ʻO ka hoʻonui ʻana i ka helu o nā lauoho hope, i wehewehe ʻia he lauoho ʻoi aku ma mua o 60 microm i ke anawaena, ma kahi i koho ʻia (0.5 cm square = 0.25 cm2 area) o nā kumuhana procyanidin B-2 ma hope o ka hoʻokolokolo 6-mahina. ma mua o nā kumuhana o ka hui hoʻomalu placebo (procyanidin B-2, 1.99 +/- 2.58 (mean +/- SD)/0.25 cm2; placebo, -0.82 +/- 3.40 (mean +/- SD)/0.25 cm2; Ua helu ʻia ʻo ka piʻi ʻana o ka lauoho hope ma kahi i koho ʻia o nā kumuhana procyanidin B-2 ma hope o ka hoʻāʻo ʻana o 6 mahina i ʻoi aku ka nui ma mua o ka mea i ʻike ʻia ma nā kumuhana placebo control group (P

Hōʻike kēia mau hopena i nā kāne i hoʻohana i ka PB2 i piʻi nui i ka nui o ka lauoho i ulu, ka helu o nā lauoho hope, a ʻaʻohe hopena i hōʻike ʻia.

I ka hoʻohālikelike ʻana o nā mea noiʻi i kā lākou hopena me nā lāʻau lapaʻau i loaʻa i kēia manawa, ua ʻike lākou ʻo ka procyanidin B-2 ka mea i emi iki ka ulu ʻana o ka lauoho ma mua o ka minoxidil (ma 2%, ʻaʻole 5%), akā ʻoi aku ka nui o ka nui o ka lauoho ma mua o ka finasteride (Proscar). ʻAʻole like me kēia mau lāʻau lapaʻau, ʻaʻohe hopena ʻaoʻao o ka procyanidin B-2. Hōʻike ka lāʻau Procyanidin B-2 i ka hiki ke lilo i mea lapaʻau palekana a hoʻohiki no ka ʻōhule kāne kāne.

ʻO kekahi noiʻi lapaʻau ʻē aʻe, i lōʻihi no 12 mau mahina, ua noiʻi i ka pono o 0.7% apple procyanidin oligomers (eia hou, he haʻahaʻa haʻahaʻa akā he koʻikoʻi nā hopena).

Ua hana ʻia kahi hoʻokolohua lapaʻau pālua-makapō e pili ana i ka huina o 43 mau kumuhana. ʻO 21 mau kāne i ka hui procyanidin a me 22 mau kāne i ka hui hoʻomalu placebo i hoʻopaʻa ʻia i ka nānā ʻana. I nā mahina 6 mua, ua hoʻohālikelike mākou i ka procyanidin a me nā hui placebo e loiloi i nā hopena lāʻau o ka procyanidin oligomers. Ua hoʻonui ʻia ka manawa noi o ka hui procyanidin i 12 mau mahina, a ua nānā ʻia ka manawa o kāna waiwai hoʻoponopono.

ʻO ka piʻi ʻana o ka nui o ka lauoho ma kahi ʻāpana poʻo i koho ʻia o nā kumuhana procyanidin ma hope o ka hoʻāʻo ʻana he 6 mau mahina i ʻoi aku ka nui ma mua o nā kumuhana placebo control group (procyanidin, 3.3 +/- 13.0 (mean +/- SD)/ 0.50 kenimika(2); ʻelua laʻana t-hōʻoia). Ua ʻike ʻia ka hoʻomaikaʻi ʻana o ka manawa i ka lauoho lauoho i nā kumuhana procyanidin. ʻAʻole i ʻike ʻia nā hopena ʻino i kekahi o nā kumuhana. Hōʻike ʻo Procyanidin therapy i ka hana ulu lauoho.

ʻO ka Pharmacology & Pharmacokinetics o Procyanidin B-2

ʻO Pharmacology ka lālā o ka lāʻau lapaʻau e pili ana i ka hoʻohana ʻana, nā hopena, a me nā ʻano hana o nā lāʻau lapaʻau.

ʻO Pharmacokinetics ka lālā o ka lāʻau lapaʻau e pili ana i ka neʻe ʻana o nā lāʻau i loko o ke kino.

ʻAʻole pono wale ka nānā ʻana a me ka noʻonoʻo ʻana i nā hana o ka hana no PB-2, he mea nui e nānā i ke ʻano o kēia mea hoʻohui e hiki ke komo, komo, a loaʻa i ka biologically ke hoʻohana ʻia ma luna.

Ua nānā kēia haʻawina i ke komo ʻana o ka PB2 i loko o kahi lotion me 0.0663mg wale nō. Ua hōʻike ʻia nā hopena ma muli o ka haʻahaʻa haʻahaʻa o ka lotion, ua hoʻohana ʻia ka waiwai e pili ana i nā pharmacokinetics.

ʻO ka manaʻo 4-5% ka manaʻo o PB2 pono e hāʻawi a komo pono, akā ʻo ka mea hoʻomaʻemaʻe aʻu i hoʻolimalima e hōʻoia iaʻu inā hiki kēia.

He mea ʻawaʻole kēia a palekana no ka hoʻohana ʻana?

No ka loiloi ʻana i ka palekana o ka procyanidin B-2 topical ma ke ʻano he mea ulu lauoho, ua nānā kēia haʻawina i ka mutagenicity, acute subcutaneous injection, irritation primer, sensitization ili, a me ka huhū o ka maka o kēia pūhui. Ua hōʻike nā hopena i kēia pūhui ʻaʻohe hopena mutagenic, ʻaʻohe aberrations structural aberrations, ʻoi aku ka nui o ke ʻano o ke kānāwai ma mua o 2000mg (subcutaneous injection), ʻaʻohe ukiuki mua ma waena o nā hoʻāʻo ʻana i nā rapeti, a me ka huhū liʻiliʻi ke hoʻokomo ʻia i loko o nā maka rabbit.

ʻAʻole i hōʻike ʻia nā hoʻokolohua lapaʻau mua i ke kanaka ʻaʻole i hōʻike ʻia nā hopena ʻino. ʻO nā haʻawina i haʻi mua ʻia e pili ana i nā hiʻohiʻona murine i hōʻike ʻole i nā hopena ʻino.

Hōʻike kēia mau hopena e palekana a ʻae ʻia ka procyanidin b-2 topical no ka hoʻohana.

I ka hopena, loaʻa i ka Procyanidin B-2 ka mana nui a ke ʻimi mau ʻia nei no kāna mau pono olakino. ʻO ka manaʻo o Aogubio i ka hoʻomohala ʻana i nā nutraceuticals, nā mea hoʻohui a me nā huahana no nā ʻoihana like ʻole e hoʻohana ana iā Procyanidin B-2 e hōʻike ana i ka manaʻo o ka hui e hoʻohana i ka mana o nā mea kūlohelohe e hoʻomaikaʻi ai i ke olakino kanaka. Ke hoʻomau nei ka noiʻi a me ka hoʻomaopopo ʻana i ka Procyanidin B-2, ʻike maopopo ʻo Procyanidin B-2 ikaika e paʻa i ka ʻōlelo hoʻohiki nui no ka wā e hiki mai ana o ke olakino kūlohelohe.

Miranda Zhang