Pākuʻi Ola Ursodeoxycholic Acid

ʻO ka ursodeoxycholic acid (ursodiol a i ʻole UDCA) kahi mea hana nui o ka bea bile i hoʻohana nui ʻia i ka lāʻau lapaʻau kuʻuna Kina no ka hoʻoikaika ʻana i ke kahe o ka bile (choleretic effect). He ʻakika bile lua ia ma muli o nā hana bacteria i loko o ke kolonā, a aia ma ke ʻano he hapa liʻiliʻi o ka nui o nā ʻakika bile i loko o ke kanaka. Eia nō naʻe, hoʻololi ia i ka hui ʻana o ka bile acid, e hoʻemi ana i ka neʻe ʻana o ka nui o ka hydrophobic a me ka cytotoxic bile acids. Eia kekahi, ua manaʻo kekahi mau haʻawina e pale ka ursodeoxycholic acid i nā hepatocytes mai ka bile acid-induced apoptosis. I kēia mau lā, hoʻohana nui ʻia ka ursodeoxycholic acid no ka mālama ʻana i nā maʻi ate cholestatic.