N-Acetylcysteine ​​a me kona hiki ke pale aku i ka poino o ke akepaa

Loaʻa pinepine ʻia ka N-Acetylcysteine ​​​​(NAC) i loko o ka capsule a i ʻole ka pauka a ua loaʻa ka ʻike no kona hiki ke pale i ka pōʻino o ka ate. He kino koʻikoʻi ka ate no ka hoʻololi ʻana i nā lāʻau a me nā mea ʻawaʻawa, a ʻo ka lōʻihi o ka ʻike ʻana i kekahi mau lāʻau e hiki ke hōʻeha i ka ate. Ma kēia ʻatikala, e ʻimi mākou i nā pono o ka N-Acetylcysteine ​​​​a pehea e hiki ai iā ia ke pale i ke ake mai ka pōʻino i hoʻohana ʻia i ka lāʻau.

ʻO N-Acetylcysteine, kahi mea mua i ka cysteine ​​amino acid, ua ʻike ʻia no kāna mau waiwai antioxidant. Hoʻohana ia ma ka hoʻopiha ʻana i ka glutathione, kahi antioxidant ikaika i loaʻa maoli i loko o ke kino, no laila e pale ana i nā cell mai ke kaumaha oxidative. ʻO kēia kaʻina hana e hana ai ʻo NAC i moho hoʻohiki no ka pale ʻana i ka hōʻeha o ka ate i ka lāʻau, no ka mea, he koʻikoʻi ko ke koʻikoʻi oxidative i ka hoʻomohala ʻana i ka pōʻino o ka ate.

Ua hōʻike kekahi mau haʻawina i ka hiki o ka N-Acetylcysteine ​​​​ke pale aku i ka pōʻino o ka ate i hana ʻia e nā lāʻau lapaʻau like ʻole. No ka laʻana, ʻo ka acetaminophen (paracetamol) kahi analgesic i hoʻohana nui ʻia e hiki ke hōʻeha i ka ate i nā hihia o ka overdose. Ua hōʻike ʻia ʻo NAC i ka hoʻēmi ʻana i ka hepatotoxicity acetaminophen-induced ma ka pale ʻana i ka pau ʻana o ka glutathione, ka hoʻemi ʻana i ke kaumaha oxidative, a me ka hōʻemi ʻana i ka hana ʻana o nā metabolites ʻona.

Ma waho aʻe o ka acetaminophen, nā lāʻau lapaʻau ʻē aʻe e like me nā lāʻau anti-inflammatory nonsteroidal (NSAIDs), statins, a me kekahi mau lāʻau antibiotic i pili pū me ka hepatotoxicity. Ua hōʻike ʻo N-Acetylcysteine ​​i ka ʻōlelo hoʻohiki i ka pale ʻana i ka pōʻino o ke ake i hoʻoulu ʻia e kēia mau lāʻau. Ma ka hoʻokaʻawale ʻana i nā metabolites ʻona, hōʻemi i ka mumū, a me ka hoʻoulu ʻana i ka hana hou o ka ate, hiki i ka NAC ke pale i ka holomua o ka hōʻino ʻana i ka lāʻau a mālama i ka hana ate.

Eia kekahi, ua aʻo ʻia ka N-Acetylcysteine ​​​​no kona pono i ka pale ʻana i ka pōʻino o ka ate i nā poʻe me kekahi mau maʻi olakino. No ka laʻana, ʻike pinepine ka poʻe me ka maʻi hepatitis C mau i ka piʻi ʻana o ka fibrosis ate a me ka cirrhosis. Ua hōʻike ʻia nā haʻawina e hiki i ka hoʻohui NAC ke hoʻomaikaʻi i ka hana o ka ate i kēia mau maʻi, no ka mea, kōkua ia e hōʻemi i ka mumū a me ke kaumaha oxidative.

Ma waho aʻe o kāna mau mea pale i ka ate, ua noiʻi ʻia ʻo N-Acetylcysteine ​​​​no kona hiki ke mālama i nā kūlana ʻē aʻe e like me nā maʻi hanu, nā maʻi psychiatric, a me ka hoʻohana ʻana i ka lāʻau. Ua hoʻohana ʻia ia ma ke ʻano he mucolytic agent i nā kūlana e like me ka maʻi pulmonary obstructive maʻi (COPD) a me ka cystic fibrosis, kahi e kōkua ai e wāwahi i ka mucus a hoʻomaikaʻi i ka hoʻomaʻemaʻe ea. Eia kekahi, ua hōʻike ʻo NAC i ka ʻōlelo hoʻohiki i ka mālama ʻana i nā maʻi psychiatric e like me ka maʻi bipolar a me ka maʻi obsessive-compulsive ma muli o kāna kuleana i ka hoʻololi ʻana i nā pae glutamate i ka lolo.

I ka hopena, ʻo N-Acetylcysteine ​​​​i loko o ka capsule a i ʻole ka pauka e paʻa i ka hiki ke pale i ka pōʻino o ka ate. ʻO kāna mau waiwai antioxidant a me ka hiki ke hoʻopiha i ka glutathione e lilo ia i moho kūpono no ka hoʻēmi ʻana i ke kaumaha oxidative a me ka hōʻemi ʻana i ka hōʻeha ate i hoʻokumu ʻia e kekahi mau lāʻau. Eia kekahi, ua hōʻike ʻo NAC i ka ʻōlelo hoʻohiki i ka mālama ʻana i nā maʻi olakino ʻē aʻe e like me ka hanu a me nā maʻi psychiatric. Eia nō naʻe, he mea nui e nīnau i kahi ʻoihana mālama olakino ma mua o ka hoʻomaka ʻana i ka hoʻohui N-Acetylcysteine ​​​​no ka mea aia paha nā ʻano like ʻole i ka dosage a me ke kūpono.