Loaʻa ʻia ka Arbutin ma ka hana ʻana i ka glucose me ka hydroquinone i unuhi ʻia mai nā lau bilberry, nā lau cranberry, nā lau pear, nā hua bear, a me nā blueberries, nā mea maoli i nā wahi mauna. ʻO ka molecular structure o arbutin ka hydroquinone i hoʻopili ʻia i ka glucose. Hoʻopaʻa ʻo Arbutin i ka hana o tyrosinase, ka mea i komo i ke kaʻina hana o ka melanin synthesis i ka ʻili, hoʻopau i ka hōʻiliʻili nui o ka melanin, hoʻemi i ka pigmentation, kōkua i ka hoʻokaʻawale ʻana i ka ʻili, a pale i nā kiko a me nā freckles. Hoʻokaʻawale ʻia ʻo Arbutin i α-type a me β-type ma muli o ka pili ʻana o ka glucose a me ka hydroquinone.
β-Arbutinhana ʻia e ka hoʻohui kemika. ʻO ka β-Arbutin he haʻahaʻa haʻahaʻa haʻahaʻa ma mua o ka α-arbutin a hiki ke haki ʻia e nā kukuna UV a me ka wela. Ma muli o kēia ʻano, ʻōlelo ʻia e hoʻohana i nā huahana mālama ʻili me ka β-arbutin wale nō i ka pō, a ke hoʻohana ʻia i ke ao, ʻōlelo ʻia e hoʻohana pū me ka sunscreen. Loaʻa iā ia ka hemahema o ka hoʻohaʻahaʻa maʻalahi ʻia e nā enzyme intracellular ma muli o ke kūpaʻa intracellular haʻahaʻa i hoʻohālikelike ʻia me α-arbutin. ʻO ka α-arbutin ka mea e uku ai i kēia hemahema.
- No CAS: 497-76-7
- Helu EC: 207-850-3
- Huina mole: C12H16O7
α-Arbutinhiki ke hana wale ia ma o ka enzymatic synthesis (microbial fermentation). ʻAʻole like me ka β-arbutin, kūʻokoʻa ia i ka māmā a me ka wela, no laila hiki ke hoʻohana ʻia i ke ao a me ka pō a hana paʻa i loko o ke kelepona, e ʻoi aku ka maikaʻi a ʻaʻohe mea ʻawaʻawa. Ma ka uku ʻana i nā hemahema o ka β-arbutin, ʻoi aku ka paʻa o ka structurally a ʻaʻole hiki ke haki. ʻO ka α-Arbutin ma kahi o 10 mau manawa ʻoi aku ka ikaika ma mua o ka β-arbutin i ka pale ʻana i ka melanogenesis. Kāohi ʻo α-Arbutin i ka tyrosinase e hoʻokaʻawale i ka ʻili o ka ʻili a hoʻemi i nā wahi kahiko, ʻeleʻele ʻeleʻele, ʻulaʻula ma hope o nā kīnā, a me nā mea hou aku. Loaʻa iā ia nā waiwai antiseptic a me nā anti-inflammatory.
- Helu CAS: 84380-01-8
- Helu EC: 617-561-8
- EINECS/ELINCS: 440-470-8
- Huina mole: C12H16O7
He aha nā mea like ma waena o Arbutin a me Alpha Arbutin?
- ʻO Arbutin a me alpha arbutin nā hydroquinones glycosylated.
- ʻO Alpha Arbutin kekahi o nā ʻano ʻelua o ka arbutin.
- Loaʻa nā mea ʻelua mai nā kumu kūlohelohe.
- Kāohi lākou i ka hana tyrosinase.
- No laila, ke kāohi nei lākou i ka hana ʻana o ka melanin.
- Hoʻemi nā ʻano ʻelua i ka pigmentation o ka ʻili e ka radiation UV mai ka lā.
- Eia kekahi, hana ʻo arbutin a me alpha arbutin e like me nā mea hoʻomālamalama ʻili.
He aha ka ʻokoʻa ma waena o Arbutin a me Alpha Arbutin?
ʻO Arbutin ka hydroquinone glycosylated e kāohi ana i ka tyrosinase, e pale ana i ka hoʻokumu ʻana o ka melanin, ʻoiai ʻo alpha-arbutin kekahi o nā ʻano ʻelua o ka arbutin i ʻoi aku ka pale ʻana i ka wela, e hōʻike ana i ka paʻa māmā a me nā waiwai solubility wai kiʻekiʻe ma mua o ke ʻano ʻē aʻe. No laila, ʻo kēia ka ʻokoʻa nui ma waena o arbutin a me alpha arbutin. ʻO ka manaʻo palekana no ka hoʻohana ʻana i ka arbutin ma ke ʻano o ke ʻano alpha he 2%, a ʻo ke ʻano beta he 7%.
Hōʻike ka ʻikepili ma lalo nei i nā ʻokoʻa ma waena o arbutin a me alpha arbutin ma ke ʻano papa no ka hoʻohālikelike ʻaoʻao.
Pehea ka hana ʻana o ka arbutin i kou ʻili?
E like me kā mākou ʻike, i ka wā e hoʻoulu ʻia ai nā melanocytes ʻili e nā kukui ultraviolet o waho, e hana lākou i ka tyrosinase, e hui pū me ka tyrosine i loko o ke kino e hana i ka dopamine, a hoʻokumu i ka melanin ma o REDOX, decomposition a me decarboxylation reactions. Lawe ʻia ka Melanin, ka puaʻa e pili ana i ka waihoʻoluʻu o ka ʻili, i ka papa basal, dermis, epidermis a me nā papa hana ʻili ʻē aʻe, a laila me ka hoʻoheheʻe ʻana a i ʻole ka ʻōnaehana kahe koko. Eia nō naʻe, inā nui ka melanin, ʻaʻole hiki ke hoʻololi ʻia e ke kino e hoʻoheheʻe ʻia i loko o ka papa epidermal e hana i kahi ʻili. ʻO kekahi mau mea e like me ka hydroquinone (hydroquinone), arbutin, phenylethylresorcinol, a me ka waikawa azelaic hiki ke hoʻopaʻa pono i ka paʻa ʻana o tyrosinase i tyrosine a keʻakeʻa i ka melanin.
Hoʻopili maikaʻi ʻo Arbutin me ka enzyme tyrosinase e hoʻopaʻa i ka synthesis o ka melanin. He mea ʻoi loa ia i ka hydroquinone (i pāpā ʻia ma ʻEulopa a me Australia) akā ʻoi aku ka maʻalahi o ka ʻili. ʻAʻole like me ka hydroquinone, kahi mea hoʻomālamalama ʻili ikaika e hiki ke hoʻoikaika nui i ka ʻili, ʻo ka arbutin kahi mea palekana a kūlohelohe. I ka pōkole, hana ka beta arbutin ma ka hoʻokūkū hoʻokūkū i ka tyrosine. Mālama kēia i ka hana ʻana o ka melanin, e ʻoi aku ka māmā a me ka māmā o kou ʻili - a me ka hyperpigmentation e mae, nā ʻāpana makahiki, nā lā a me nā ʻeleʻele.
Ka manawa hoʻouna: Jul-11-2023
