He aha ka Nattokinase?
ʻO ka Nattokinase (NK) he Bacillus subtilis protein kinase, he serine protease i hana ʻia e Bacillus subtilis natto i ka wā o ka fermentation o ka natto. Loaʻa iā ia nā hana o ka hoʻopau ʻana i nā clots koko, hoʻemi i ka viscosity koko, hoʻomaikaʻi i ke kahe koko, palupalu a hoʻonui i ka elasticity vascular.
I ka makahiki 1980, ua ʻike ʻia ma Natto he 275 amino acids i hoʻonohonoho ʻia ma ke ʻano paʻa, me ke kaumaha molekala o 27724. He hana kūʻokoʻa ia o ka decomposing blood clots, a ua hōʻike ʻia kona hopena ikaika e ka intrinsic unit FU.
ʻAno kino a me kemika
Hoʻopau koke ʻo Nattokinase a hoʻopau i nā mahana ma mua o 80 ℃, akā ʻaʻole liʻiliʻi ka hopena o ka hoʻoheheʻe ʻana i ka hau.
Hoʻopaʻa ka Nattokinase i loko o 10 mau minuke ke piʻi ka pH waiwai mai 7 a 12; Ke emi ka pH ma lalo o 5, hikiwawe ke denature a lilo ʻole.
Ma hope o ka hoʻohui ʻana i ka nattokinase me nā mea viscous, hiki iā ia ke mālama i ka hana ʻaʻole iʻoi aku ma mua o 7.5% i loko o kahi ʻakika me ka pH waiwai o 2-3.
ʻO ka Nattokinase kahi mole nui hoʻokahi kaulahao peptidase hiki ke wāwahi ʻia i nā ʻāpana amino acid a i ʻole nā kaulahao peptide paona liʻiliʻi liʻiliʻi e nā wai digestive ʻōpū (chymotrypsin, trypsin, wai ʻōpū liʻiliʻi, etc.).
Ka waiwai waiwai o ka natto
ʻO ka Natto kahi meaʻai hana i hana ʻia mai ka soybean i hoʻomoʻa ʻia me ka bacteria. Ma waho aʻe o ka mālama ʻana i nā meaʻai o ka soya maka, ʻoi aku ka kiʻekiʻe o kekahi mau mea e like me ka protein, fiber, calcium, iron, potassium, a me nā huaora ma mua o ka soybean i kuke ʻia.
ʻO ka maʻiʻo o ka biotin B1, ka huaora B2, a me nā minela ʻē aʻe, ʻoi aku ka nui o ka calcium, ka hao, a me ka potassium, ʻoi aku ma mua o nā hua. Inā hoʻohālikelike ʻia ka natto me nā hua manu a me ka pipi, ʻo ka nui o ka protein o 100g o ka natto e like me 3 hua a i ʻole 80g o ka pipi. He waiwai nui ka amino acid i loko o ka natto, ma muli o ka hana ʻana o nā huaora a me nā enzymes i ka wā o ka fermentation, e like me amylase, protease, lipase, cellulase, nattokinase, lysozyme, glutamic acid transpeptidase, etc. ʻO ka hana o nā enzymes, ka protein a me nā meaʻai ʻē aʻe e decomposed, no laila ʻoi aku ka kiʻekiʻe o ka digestion o ka natto (85%) ma mua o ka soybean moʻa. (68%), ʻoi aku ka meaʻai a maʻalahi hoʻi e komo.
Ka noiʻi kuleana
ʻO ka NattoKinase (NK) he pūmua me ka paona molekala i ʻoi aku ka liʻiliʻi ma mua o UK, SK, a me tPA, i unuhi ʻia mai ka natto meaʻai a i hoʻomoʻa ʻia e ka bacteria natto. Hiki ke komo ʻia e ka ʻōpū. Ua hoʻoholo ʻia nā waiwai thrombolytic in vitro a me in vivo o NK ma o nā hoʻokolohua, a ua ʻike ʻia ʻo ka hana thrombolytic in vivo o NK ʻehā mau manawa o ka fibrinolytic enzyme. Hana wikiwiki a lōʻihi ka manawa i loko o vivo, a hiki nō hoʻi ke hoʻoikaika i ka tPA i ke kino, e ʻoluʻolu e hoʻomaikaʻi mau i ka hana fibrinolytic o ke koko. ʻO nā mea maʻi i ka pilikia o ka myocardial infarction pono e hoʻokomo i 300000 mau ʻāpana o ka urokinase i ka manawa, a ʻo 50 grams o ka natto i loko o 800000 mau ʻāpana urokinase no ka thrombolysis.
Nā hana nui
ʻO ka hopena koʻikoʻi o ka nattokinase he mea maikaʻi loa ia e kūʻē i nā clots koko kahiko. Loaʻa ka Nattokinase i ka hopena thrombolytic pololei ma ka hydrolyzing i ka fibrin nui o ka thrombus, a ʻo ia wale nō ka mea maoli i ʻike ʻia e hoʻopau i ka thrombus kahiko.
I ka makahiki 2015, ua alakaʻi ʻo Tokyo Medical University i kahi hoʻokolohua thrombolytic me ka nattokinase i loko o ke kanaka, e hōʻoia ana e hiki i ka nattokinase ke hoʻonui i ka hiki fibrinolytic o ke kino a hoʻopau maikaʻi i nā clots koko. Ua kapa ʻia ka hōʻike noiʻi "Single dose oral nattokinase thrombolysis and anticoagulation enhancement" a ua paʻi ʻia ma ka Scientific Reports 2015; 5: 11601.
Ma 2016, ma kahi hoʻokolohua thrombolysis 48 hola, ua hoʻohana ʻia ʻo 300FU o nattokinase i ka thrombi kahiko ma luna o 56 mau hola, e hōʻike ana ua hemo loa ka thrombus i loko o 2 mau hola; ʻOi aku ka kiʻekiʻe o ka thrombolysis o ka hoʻohana ʻana i ka 150FU nattokinase ma mua o ka hoʻohana ʻana i ka like like o ka urokinase [1]. Ua hōʻike ʻia ka noiʻi ʻaʻohe hopena o ka nattokinase i ka fibrinogen plasma, e emi ana ka maʻi o ke koko. Hiki iā ia ke hoʻoikaika pono i ke ʻano thrombolytic ponoʻī o ke kino, e pale i ke kino i ka thrombosis ma o ka hoʻohana lōʻihi ʻana, a laila e hōʻoia ai i ke olakino cardiovascular a me ka cerebrovascular.
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Ka manawa hoʻouna: Sep-11-2023
