Deoxyarbutin, ma ke ʻano he mea hoʻokūkū ʻo Tyrosinase inhibitor, hiki ke hoʻoponopono i ka hana ʻana o ka melanin, lanakila i ka pigmentation, hoʻopau i nā ʻeleʻele ʻeleʻele o ka ʻili, a loaʻa i ka hopena keʻokeʻo ʻili wikiwiki a mau loa. ʻOi aku ka maikaʻi o ka hopena inhibitory o deoxyaarbutin ma Tyrosinase ma mua o nā mea hana keʻokeʻo ʻē aʻe, a hiki ke hoʻokō ʻia ka hopena keʻokeʻo a me ka hoʻomālamalama me ka liʻiliʻi o ka hoʻohana. Loaʻa i ka Deoxyarbutin nā hopena antioxidant ikaika
- ʻO ka inoa Pākē ʻo Deoxyarbutin
- Deoxyarbutin inoa haole
- Kapa inoa p - (tetrahydro-2H-pyran-2-oxy) phenol
- Huina kemika C11H14O3
- Kaumaha Molekala 194.23
- Helu helu helu CAS 53936-56-4
- ʻO ka inoa Pelekane 4- [(Tetrahydro-2H-pyran-2-yl) oxy] phenol
- Maʻemaʻe ≥ 98%
Deoxyarbutinma ke ʻano he hanauna hou o ka cosmetic brightening a me ka whitening active agent, ua hoʻohana nui ʻia i nā mea hoʻonaninani keʻokeʻo kiʻekiʻe.
Hoao
Hiki ke hoʻokō ʻia ka hoʻololi ʻana o ka melanogenesis i loko o nā melanocytes me ka hoʻohana ʻana i nā kemika e kaʻana like i nā homologies structural me ka tyrosine substrate a pēlā e hoʻokūkū ai i ka hana catalytic o tyrosinase. Ua hoʻomohala mākou i kahi mea hoʻopaneʻe tyrosinase hou, deoxyArbutin (dA), e pili ana i kēia kumu. Hōʻike ʻo DeoxyArbutin i ka pale ʻana i ka mushroom tyrosinase in vitro me kahi Ki he 10-fold ka haʻahaʻa o ka hydroquinone (HQ) a me 350-fold haʻahaʻa ma mua o arbutin. I loko o kahi kumu hoʻohālike puaʻa puaʻa huluhulu ʻole, ua hōʻike ʻo dA i ka māmā ʻana o ka ʻili i hiki ke hoʻohuli ʻia i loko o 8 mau pule ma hope o ka hoʻomaha ʻana i ka noi topical.
ʻO ka hoʻohālikelike ʻana, ua hoʻokomo ʻo HQ i kahi hopena uila pōkole akā ʻaʻole hoʻomau ʻia ʻoiai ʻo kojic acid a me arbutin ʻaʻole hōʻike i ka hopena uila. Ua kākoʻo nā hualoaʻa mai kahi papa hoʻāʻo palekana i ka hoʻokumu holoʻokoʻa ʻana o dA ma ke ʻano he moleke hiki ke hana. I loko o kahi hoʻokolohua lapaʻau kanaka, ʻo ka hoʻomaʻamaʻa topical o dA no nā pule he 12 i hopena i ka hōʻemi nui a i ʻole ka emi iki o ka māmā o ka ʻili holoʻokoʻa a me ka hoʻomaikaʻi ʻana o nā lentigines o ka lā i ka heluna kanaka o ka ʻili māmā a i ʻole nā ʻili ʻeleʻele, kēlā me kēia. Hōʻike kēia mau ʻikepili e loaʻa ana i ka dA kahi hana hoʻopaʻa tyrosinase hiki ke hopena i ka uila a hiki ke hoʻohana ʻia e hoʻomaikaʻi i nā ʻeha hyperpigmentary.
Hoʻolauna
ʻO ka Melasma (chloasma) kahi maʻi ʻili ʻili maʻamau i hōʻike ʻia e ka māmā ʻole a hiki i nā ʻāpana ʻeleʻele ma ka maka, ka mea maʻamau e hoʻokau i nā kaumaha psychiatric a noʻonoʻo no ka poʻe i hoʻopilikia ʻia. Eia naʻe, ʻaʻole maopopo i nā hanana hoʻonāukiuki no ka pathogenesis o ka melasma. ʻOi aku ka maʻamau o ka Melasma i nā poʻe me nā ʻano ʻili Fitzpatrick IV a hiki i VI ma mua o ka poʻe me ka ʻili maikaʻi (ʻano I a hiki i III). Ua ʻike ʻia ʻo Melasma i mea maʻamau i waena o nā wahine ma mua o nā kāne a ʻoi aku ka maʻamau i waena o nā ʻAsia, Latinos a me ʻApelika-ʻAmelika ma mua o nā Caucasians. Ma kahi o 50% a 70% o nā wahine hāpai i ka US e hoʻomohala i ka melasma [3].
Ua hoʻokumu ʻia ʻo ka hyperactive melanocytes i ka ʻili melasma e hoʻonui i ka puaʻa melanin ma o ke ala tyrosine catabolism. ʻO Tyrosinase (EC 1.14.18.1), he glycoprotein i loko o ke keleawe, ʻo ia ka enzyme e kaupalena ana i ka nui no kēia ala. Hana ʻia ka melanin synthesis i loko o nā organelles kūikawā i kapa ʻia he melanosomes a laila hoʻololi ʻia nā melanosome melanized mai nā melanocytes i nā keratinocytes kokoke, a laila e hoʻoholo ai i ka waihoʻoluʻu o ka ʻili. ʻO ka nui o nā mea hoʻomaʻamaʻa ʻili i manaʻo ʻia i ka mālama ʻana i ka melanin synthesis ma o ka hoʻopau ʻana i ka hana tyrosinase. I nā makahiki he 50 i hala iho nei, ua hoʻohana nui ʻia ka hydroquinone (1, 4-benzenediol, HQ) ma ke ʻano he kumu gula no ka prototypical tyrosinase inhibitors i ka mālama ʻana i ka melasma. Eia nō naʻe, ua nui ka nānā ʻana i ka pilikia olakino o ka loaʻa ʻana o ka HQ i ka wā lōʻihi, e like me ka exogenous ochronosis, leukoderma (occupational vitiligo), a me ka carcinogenesis. hana, hāʻawi i ka hiki o ka ili whitening. I kēia manawa, hāʻawi pū kēia mau pūhui monophenol, ma o ka enzymatic oxidation e tyrosinase, i ka nui o nā radical manuahi e hoʻopiʻi ai i ka lipid peroxidation a me ka hopena melanosomal membrane pohō. -pyran-2-yl) oxy] phenol, D-Arb), he glucoside derivative o HQ, palekana a emi mai. cytotoxic ke hoʻohālikelike ʻia me kona makuahine pūhui hydroquinone. Ua hana ʻia kēia haʻawina e noiʻi i ka ʻona a me ka pono o D-Arb ma ka pae sub-cellular (pololei ma nā melanosomes) a me ka pigmentation ʻili e hoʻohana ana i nā hiʻohiʻona in vivo a in vitro, e loiloi hou ana i ka biosafety o D-Arb i ka hoʻohālikelike like me HQ no ka hoʻohana ʻana i ka ʻili.
Deoxyarbutin, ma ke ʻano he hanauna hou o ka hoʻomaʻamaʻa hoʻonaninani a me ka mea hana keʻokeʻo, hoʻohana nui ʻia i nā mea hoʻonaninani keʻokeʻo.
ʻO D-Arbutin kekahi o nā derivatives o Arbutin, i kapa ʻia ʻo D-nenenebb arbutin, hiki ke kāohi pono i ka hana o tyrosinase i loko o ka ʻili ʻili. Wahi a ka noiʻi, ʻo kona hopena he 10 mau manawa ma mua o ka hydroquinone a me 350 mau manawa o ka general Arbutin. Ma nā ho'āʻoʻana o kaʻili holoholona, hiki i kēia D-Arbutin ke hoʻomaʻemaʻe wikiwiki i kaʻili, a ma hope o ka hoʻopauʻana i ka hoʻohanaʻana, hiki ke mālamaʻia ka hopena no nā wiki he 8.
Ma nā haʻawina hoʻonaʻauao e pili ana i ke kino kanaka, hiki i ka hoʻohana topical o D-Arbutin no nā wiki he 12 ke hoʻokō i nā hopena uila nui, a he hopena hoʻomaikaʻi maikaʻi i kēlā me kēia lā i nā wahi mālamalama a me nā kūlana ʻili ʻeleʻele.
Ka manawa hoʻouna: Jul-11-2023
